The family of late locked-in syndrome sufferer Tony Nicklinson and paralysed road accident victim Paul Lamb have lost their right-to-die challenges.The Court of Appeal upheld a High Court judgement in the case of the late Mr Nicklinson, ruling he did not have the right to ask a doctor to end his life.His widow, Jane, said she planned to appeal to the Supreme Court.Mr Lamb has said he wanted the law changed so he could kill himself with a doctor's help.Jane Nicklinson told the BBC she was "very, very disappointed" by the ruling, but "not totally surprised"."They are not going to get rid of us that easily," she said, as she explained she would be seeking permission to appeal to the Supreme Court.She added that it was a very complicated legal matter."Although we lost, the legal team are quite pleased with the outcome - the appeal judges actually upheld a couple of points which the High Court rejected, which is a step forward."Mr Nicklinson died naturally at his home in Wiltshire last year.