A Ugandan national army soldier has shot and killed a government minister he was guarding.

Retired Colonel Charles Okello Engola, who was the deputy minister for gender and labour, was shot at his home on Tuesday morning.

It is not yet clear whether there was an argument between the soldier and Col Engola.

The soldier, yet to be officially identified, then shot himself dead.

Before turning the gun on himself, some eyewitnesses said the soldier walked around the neighbourhood shooting in the air.

Initial reports suggest a number of people may be injured and videos on social media showed locals gathering at the scene in shock.

Col Engola was a senior government official and had previously served as a deputy minister for defence.

The speaker of Uganda's parliament confirmed Col Engola's death in a short statement while presiding over the morning session.

"This morning I received sad news that Hon Engola has been shot by his bodyguard and after, shot himself. May his soul rest in peace. That was God's plan. We can't change anything," Anita Among told MPs on Tuesday.