Defending Champions, Prempeh College have defeated St. Thomas Aquinas for the third time in a row.
This sends the Accra-based one-time winners packing from the competition despite a spirited performance.
The Sunday morning loss also means St. Thomas Aquinas will start next year’s competition from the regional qualifiers once more, with Prempeh College maintaining their seeded spot.
The contest, which also included Ofori Panin SHS, ended with Prempeh leading with 46 points.
St Thomas Aquinas had 40 points while Ofori Panin had 25.
The first of this trilogy was in 2017 when the two schools faced off in the grand finale in Accra. Prempeh College fought off a last minute upset to win the title.
In 2020, Aquinas failed a revenge bid and lost to Prempeh College again - at the one-eighth stage.
Now, in 2022, again at the one-eighth stage, Prempeh dominates the contest to prove that they are five-time champions, with only Presec Legon winning more titles.
The Kumasi-based school continue their title defense in what they have promised to be a back-to-back showing.

Ofori Panin SHS who also took part in the Sunday morning square off also crush out of the tournament after placing third.
The 2022 National Science and Maths Quiz is produced by Primetime Limited and sponsored by the Ghana Education Service in partnership with Absa Ghana. It is supported by GOIL, Prudential Life Insurance, AirtelTigo, Dano Milk, Newmont, Accra College of Medicine, Academic City University College and YFM.
The broadcast of the National Science & Maths Quiz on JoyNews is supported by Virtual Infosec Africa, Virtual Security Africa, Vita Milk, Cowbell, Alumni by Enterprise Life, Faytex Toilet Roll, Ace Medical Insurance, Azar Group, Kings Group Limited, Family Health Medical School, DBS, KORBA and Lumetrust from Pharmatrust.
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