Department of Defence chief of staff Kevin Sweeney has resigned, a month after the Defence Secretary James Mattis announced his departure.
Rear Admiral Sweeney said in a statement that "the time is right to return to the private sector".
He is now the third senior Pentagon official to announce his resignation since President Donald Trump announced US forces would leave Syria.
Officials have said there is no timetable for the troop departure.
Rear Adm Sweeney held his post for two years from January 2017.
In a terse resignation letter, he said it had been an "an honour to serve" alongside his colleagues in the department, but made no mention of Mr. Trump.
His announcement comes days after General Mattis left his post early, after initially planning to stay in his role until February.
His departure adds to a sense of uncertainty surrounding the Trump administration's defence and foreign policies since the surprise announcement of the planned withdrawal from Syria, analysts say.
On Tuesday, Secretary of State Mike Pompeo will embark on a week-long tour of the Middle East designed to reassure allies in the region.
Image Caption: General Mattis announced his resignation in December
The former defence secretary hinted at policy differences with President Trump in his resignation letter.
Addressed to Mr. Trump directly, Gen Mattis's letter described his views on "treating allies with respect" and using "all the tools of American power to provide for the common defence".
"Because you have the right to have a secretary of defence whose views are better aligned with yours on these and other subjects, I believe it is right for me to step down from my position," he wrote.
Department spokeswoman Dana White also left her post after the president's surprise announcement on Syria, as did Brett McGurk, the presidential special envoy to the global coalition fighting so-called Islamic State.
Latest Stories
-
Police haul in Kwadaso MP, EC officials in probe of Ejisu by-election ‘bribery’ case
41 mins -
Ghana’s press freedom ranking: Are we actually improving?
2 hours -
Reflections: 50 Lessons at 50
2 hours -
NCCE briefs Council of State on civic plans for 2024
2 hours -
Ecobank Group reports Profit Before Tax of $581m, on net revenue of $2.1bn for 2023
2 hours -
More businesses are working to move out of Ghana – Food and Beverages Association
2 hours -
Empowering Ghana’s Environmental Narrative: Celebrating World Press Freedom Day 2024
3 hours -
AG hasn’t closed investigations into Cecilia Dapaah’s case – Spokesman
3 hours -
Ghana Tourism Authority celebrates ‘Feast Ghana’ on May Day with a Taste of Culture
3 hours -
Fella Makafui gets emotional and teary-eyed reacting to old video with Medikal
3 hours -
FBNBank Ghana changes to FirstBank Ghana to align with Group identity
3 hours -
Agogo Presby Hospital celebrates staff over zero maternal death record
4 hours -
Ghana isn’t broke to procure high and low-voltage poles – Energy Minister
4 hours -
Appiatse residents handed keys to newly constructed homes
4 hours -
Dumsor: Mahama the only President to superintend ‘dum dum’ for 4 years – Opoku Prempeh
4 hours