Di Natale last season went back on his decision to retire and started this campaign determined to match the 205-goal tally of Italian great Roberto Baggio, who is sixth on Serie A's all-time list of top scorers.
The current record is held by Silvio Piola, who retired in 1954 with 274 league goals. With 237 goals, Roma playmaker Francesco Totti is the top active goalscorer in the league.
Despite playing for Udinese, a club that has neither won the Italian league or Cup, Di Natale has won Serie A's Capocannoniere top-scorer award two years in succession.
In 2010 he scored 29 league goals to leave Inter's Diego Milito (22) a distant second and then hit the net 28 times to leave Uruguayan Edinson Cavani, then of Napoli, second by just two goals.