Raphael Dwamena will not be involved in Black Stars must-win double-header against Congo.
The in-form striker has withdrawn from the squad for 2018 FIFA World Cup qualifiers after his move to English Premier League hit the rocks.
The FC Zurich player has remained in Switzerland to undergoe further tests after a failed medical at Brighton Hove & Albion.
Dwamena wants to seek a second opinion on health status and so has decided to stay away.
A statement on the Ghana FA website read: Raphael Dwamena pulls out of Ghana squad for the World Cup qualifiers against Congo. He is undergoing further medical tests in Switzerland.''
In his absence, Red Star Belgrade striker Richmond Boakye Yiadom has been handed a late call-up to replace him.
Yiadom is a like-for-like replacement for Dwamena, considering his blistering form this term.
He scored seven goals in eight games in the Europa League qualifying round.
The 24-year old has been capped 24 times by senior national team with three goals.
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