Manchester United were knocked out of the Champions League at the last-16 stage after an awful performance ended in a 2-1 home defeat by Sevilla.
Substitute Wissam Ben Yedder was the match-winner for the Spanish side, shooting from inside the area just two minutes after coming on and heading in at the back post from a corner.
After posing little threat in the goalless first leg, United again looked second best against the La Liga side, though Marouane Fellaini's thumping effort did draw Sergio Rico into a save and the away goalkeeper kept out Jesse Lingard's low strike.
Romelu Lukaku lashed home from close range with seven minutes remaining, but it proved to be merely a consolation.
United exit the competition along with Tottenham, but Premier League leaders Manchester City and Liverpool progressed to Friday's quarter-final draw. Chelsea can join them if they beat Barcelona on Wednesday.
Have your say
More Sports Headlines
- Manchester United sack boss Mourinho
- MLS star David Accam organizes Community Soccer Gala in Accra
- Andre Ayew scores in Fenerbahce draw on his 29th birthday
- Europa League: Arsenal to meet BATE, Chelsea draw Malmo
- UCL Draw: Man Utd face PSG, Liverpool play Bayern
- Mourinho: Man Utd can still finish in the top four after Liverpool loss
- SCOREBOARD: Results from top European leagues
- Shaqiri double sees Liverpool beat Man Utd to go top
- Hazard stars as Chelsea hold on to beat Brighton
- Southampton end Arsenal's 22-match unbeaten run
- Stuttgart captain's father dies in stadium after Bundesliga game
- EPL Wrap: Man City return to top, Spurs grab late winner
- Defender Smalling signs new Man Utd contract
- 2019 Africa Cup of Nations: Caf confirms bids from SA and Egypt
- CAF CC: Kotoko hold Kariobangi to goalless draw in first leg