Rafael Nadal has been beaten in a Grand Slam for the first time in 2022, losing to Frances Tiafoe in the US Open fourth round.

American Tiafoe thrilled the home crowd with a 6-4 4-6 6-4 6-3 win over four-time champion Nadal in New York.

The defeats ended the Spaniard's bid for a record-extending 23rd major singles title.

Nadal led the fourth set 3-1 before Tiafoe hit back, winning five games in a row to secure his quarter-final spot.

He will face Russian ninth seed Andrey Rublev for a place in the semi-finals at Flushing Meadows.

More to follow.