Some 30 students of the Presbyterian Boy's Secondary School (PRESEC) at Legon in Accra have been quarantined by health officials.
This is after some students reported to the school's clinic complaining of headaches and general weakness.
There are claims that the development is another case of a Flu outbreak but the Senior Housemaster Kofi Yesu denied rumours of an outbreak.
He told Joy News that blood samples have been taken from the students and have been sent to Noguchi Medical Research Institute to determine what is the issue could be.
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