Audio By Carbonatix
A second lockdown is needed to "contain the surge", Boris Johnson has told MPs, before they vote on implementing restrictions in England.
The PM is likely to win the Commons vote on the measures later, with Labour's help - but around 20 Tory MPs could vote against them.
A four-week lockdown which includes the closure of pubs, gyms non-essential shops is due to start at midnight.
Mr Johnson said another lockdown was "not something any of us wanted to do".
Opening the debate, he added: "I am not prepared to take the risk with the lives of British people".
LIVE: MPs debate and vote on second England lockdown #coronavirus https://t.co/HcIoyczX2R
— Cheshire Live - Crewe (@CheshireLiveCrw) November 4, 2020
The restrictions will replace the three-tiers of regional restrictions across England.
One Tory rebel, former chief whip, Mark Harper said: "We have acted too soon because we are starting to see the tier system working."
Mr Johnson said he was "wrong" and the data showed hospitalisations mounting steadily, adding: "The curve is already unmistakeable."
Earlier at Prime Minister's Questions, Labour leader Sir Keir Starmer accused Mr Johnson of "ignoring" the advice of government scientists who called for a brief "circuit breaker" lockdown in September.
"Does the prime minister understand the human cost of his delay in acting?," he asked the PM.
Mr Johnson said it was "always right to pursue a local and a regional approach as our scientific advisers," adding that it was "showing signs of working".
Latest Stories
-
GoldBod has never incurred losses – Agalga challenges claims as Minority pushes probe
55 minutes -
NAIMOS raids Ankobra, destroys 86 chanfang machines in fresh galamsey crackdown
1 hour -
Trump administration moves to impose more than $100,000 fee for H-1B worker visas
2 hours -
Oil prices steady as investors weigh impact of expanded US sanctions against Iran
3 hours -
Trump administration plans to revoke visas of foreigners seeking asylum
4 hours -
US appeals court considers reassigning case from judge over AI use
4 hours -
Trump bought shares in Elon Musk’s SpaceX in June, financial disclosure shows
4 hours -
MTN approves $375 million share buyback after profit rise
4 hours -
Ghana gold buyers went weeks without funds, sources say
4 hours -
Nevada sues to block Trump administration’s Colorado River plan
5 hours -
Tunisian hospital receives 19 bodies after migrant boat sinks
5 hours -
Oil drops more than $2 despite new US sanctions on Iran
5 hours -
Dangote refinery drives seven-fold rise in Nigeria petroleum product exports, EIA says
5 hours -
Zambia closes courts on last day to file election challenge
5 hours -
Nearly three million Teslas recalled in China over hidden door handles
5 hours