David Cameron has warned Conservatives in Wales not to fall out over cuts to the number of MPs' seats at the next general election.
Wales will lose a larger share of its MPs than any other part of the UK in 2015 when boundaries are redrawn.
David Cameron told a meeting of the party's conference in Manchester he didn't want to hear of Tory disputes.
It comes as the Conservative leader in the Welsh Assembly said he is open to coalition offers.
Andrew RT Davies ruled out any "backroom deals" with other parties.
"Ultimately what we want to be is a consensual party here in Wales that people can reach across and say 'Yes, I can see what the Conservatives are doing and it makes sense'," he said.
"Now if we can get into coalition or other parties want to come into coalition with us my door is always open."
'Blue on blue'
Wales will lose 10 of its 40 Parliamentary constituencies with the boundary changes, which are expected to hit Labour harder than other parties in Wales.
However, sitting Tory MPs may find themselves competing for the same seat.
The UK government says it's fair that each seat has roughly the same number of voters.
At a private reception on Sunday, Mr Cameron told party members that he didn't want to hear of what he called "blue on blue" disputes, just "red on red" arguments.
BBC Wales parliamentary correspondent David Cornock said the comment is likely to fuel Labour complaints that the changes are partisan.
On Sunday, Andrew RT Davies made his conference debut as Tory Assembly leader as thousands demonstrated outside against UK Government cuts.
He said the Welsh Government had run out of steam and ideas on how to use the assembly's new law-making powers.
On health, he said spending on free prescriptions had left no money to pay for life-saving drugs - 24 cancer drugs were available in England but not in Wales.
Mr Davies also said the Tories would support the Welsh Government where they came forward with suitable ideas to revive the economy.
A source close to the Welsh Health Minister, Lesley Griffiths, said: "Unlike what the the Tories are doing to the NHS in England, Labour is not dismantling the NHS in Wales.
"Unlike the Tories, our waiting lists are not running out of control. Unlike the Tories, Welsh patients are not subject to a 'tablet tax' on prescriptions.
"Welsh patients are able to access cancer drugs without the English model of a cancer drugs fund.
On Monday, conference delegates will hear from the Chancellor George Osborne about his plans to tackle the struggling economy.
He is expected to announce an extension to the freeze on council tax in England.
'Empty criticism'
Treasury Minister Justine Greening confirmed to BBC Radio Wales that there will be a knock-on payment to the Welsh Government because of the announcement.
She said the coalition had decided it was important to "put the money into people's pockets" and that it would now be up to the Welsh Government to decide on its own spending priorities and where to spend the money it gets.
Speaking to BBC Radio Wales on Monday, Mr Davies said it was "complete rubbish" to suggest that the announcement on a council tax freeze in England is an attempt to grab positive conference headlines for the chancellor.
He said returning "modest sums of money" saved to the tax payer was the right thing to do.
In her party speech on Sunday, Welsh Secretary Cheryl Gillan talked about what the coalition government is doing to help Wales recover.
She also accused the Welsh Government of ducking key decisions and adopting a "timid" approach.
She told conference that Labour decisions had led to longer NHS waiting lists and a weaker economy.
But Shadow Welsh Secretary Peter Hain said her comments were "empty criticism".
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