Avram Grant has responded to criticism of his selection with six changes to the Ghana team that to Senegal on Saturday.
The Black Stars will start with Daniel Amartey after first choice Jonathan Mensah failed to recover from an injury sustained against Senegal. John Boye will be the youngster's partner.
In goal, nine after losing his spot, Fatau Dauda comes back in post ahead of the much-maligned Razak Braimah.
Harrison Afful remains one of Ghana's consistent players in the last two years, but he will have Jeffrey Schlupp coming in after the Leicester man missed the recent Afcon.
The team will play a 4-3-3, with Rabiu Mohammed and Emmanuel Agyemang Badu back in the starting lineup after six games following the overtaking performances of Afriyie Acquah and Mubarak Wakaso as the Afcon wore on.
Ghana's speedy lineup is punctuated by the presence of Christian Atsu and Frank Acheampong on the flanks with the target man being Italy-based Richmond Boakye-Yiadom, whose consolation strike against Senegal is rewarded.
Captain of the day Andre Ayew plays alongside in attack.
Ghana XI v Mali:
Fatau Dauda; Harrison Afful, Jeff Schlupp, Daniel Amartey, John Boye; Emmanuel Agyemang-Badu, Rabiu Mohammed; Frank Acheampong, Andre Ayew, Christian Atsu; Richmond Boakye-Yiadom.