At least 48 Palestinians have been killed in a series of Israeli air strikes in northern Gaza overnight, a local hospital says.

The Indonesian hospital reported that 22 children and 15 women were among the dead after a number of homes in Jabalia town and refugee camp were hit. A video shared online appeared to show at least a dozen bodies on the floor there.

The Israeli military said it was looking into the reports. It had warned residents of Jabalia and neighbouring areas to evacuate on Tuesday night after a Palestinian armed group launched rockets into Israel.

It came as the UN's humanitarian affairs chief urged members of the UN Security Council to take action to "prevent genocide" in Gaza.

Speaking at a meeting in New York on Tuesday, Tom Fletcher accused Israel of "deliberately and unashamedly imposing inhumane conditions on civilians".

He called on Israel to lift its 10-week blockade on Gaza and criticised the Israeli-US plan to take over the distribution of humanitarian aid in the territory.

The Israeli ambassador to the UN, Danny Danon, told the council that foreign aid was being used to help Hamas's war effort.

Meanwhile, US Special Envoys Steve Witkoff and Adam Boehler said they would travel to Qatar for fresh negotiations on a possible ceasefire and hostage release deal.

Israel's Prime Minister, Benjamin Netanyahu, has threatened to expand its military offensive in Gaza this week unless Hamas agrees to release the 58 hostages it is still holding.

On Tuesday, a massive Israeli air strike on the European hospital's compound in southern Gaza killed at least 28 people, according to local officials.

Israeli media reports said the target was Mohammed Sinwar, who is believed to have become the leader of Hamas in Gaza after his brother Yahya was killed by Israeli forces last October.

The Israeli military described it as "a precise strike on Hamas terrorists who were operating in a command-and-control centre" underneath the hospital.

The Israeli military launched a campaign to destroy Hamas in response to an unprecedented cross-border attack on 7 October 2023, in which about 1,200 people were killed and 251 others were taken hostage.

At least 52,908 people have been killed in Gaza since then, according to the territory's Hamas-run health ministry.