Medeama have a herculean task now in the CAF Confederations Cup, after they lost through three quick goals in eight minutes on Saturday evening in Pretoria.
Mamelodi Sundowns came from behind to secure a 3-1 win over the Mauves and Yellows in the first leg of their tie. The Ghanaians broke the deadlock inside the opening minute, as Eric Kwakwa rifled home a sublime effort that left Wayne Sandilands with no chance.
Khama Billiat went close for Sundowns after 13 minutes as his cheeky lob from close range was tipped over the bar by Tagoe.
Sundowns should have been level in the 27th minute, as Anthony Laffor weaved his way into the box and a had glimpse at goal. However, the Liberian opted lay the ball off rather take a strike at goal.
The home side went even closer in the 33rd minute. Leonardo Castro's fine back-heel released Mzikayise Mashaba, who rattled the upright from close range.
Cuthbert Malajila was brought on to replace the in-effective Laffor five minutes into the second half, as Sundowns pushed for an equaliser.
Castro squandered a glorious chance to level matters in the 58th minute, as the Colombian placed his header wide of the upright from six-yards out.
Mosimane opted for a double change after 70 minutes, introducing Teko Modise and Siyanda Zwane for Tebogo Langerman and Rama Mphahlele.
Sundowns eventually leveled matters in the 80th minute, as Castro nodded home Dolly's corner at the near post.
Mosimane's charges eventually completed the comeback in the 84th minute, as Billiat's cross-cum-shot from the right flank sailed over a flailing Tagoe and into the back of the net.
However, the hosts sealed the win a few minutes later, as Malajila calmly slotted into the bottom corner from six-yards out, 3-1.
The South African side were favorites to wrap this up, after winning their tough domestic Premiership title this week when a 3-0 win over University of Pretoria gave them an unassailable lead over Bidvest Wits.
The Brazilians, as they are called, dropped down into the Confederation Cup, Africa's second-tier club competition, after being eliminated from the CAF Champions League by AS Vita two weeks ago.
Meanwhile, Medeama have been struggling in the Ghana Premier League, where they lie tenth.
They would need a miracle to overturn this tie in Tarkwa.
Mamelodi Sundowns: Sandilands, Mphahlele, Langerman, Nthethe, Arendse, Kekana, Mashaba, Laffor, Billiat, Dolly, Castro
Medeama: Tagoe, Adade, Amoah, Aidoo, Sarpong, Boahene, Kwakwa, Akowuah, Bio, Donsu, Abass Mohammed