President Donald Trump has withdrawn all support for Republican Congresswoman Marjorie Taylor Greene, a firebrand conservative who long supported Trump's agenda but recently criticised several of his policies.

Trump said in a nearly 300-word social media post that the Georgia lawmaker had gone "far left", and called for her to be unseated in next year's midterm election by a Republican challenger.

The falling out comes after Greene questioned whether Trump was still putting "America First" on his agenda. She criticised his focus on foreign policy and handling of Jeffrey Epstein files.

Greene said Trump was lashing out to try and deter other Republicans from voting to release the files.

"All I see "Wacky" Marjorie do is COMPLAIN, COMPLAIN, COMPLAIN!" Trump posted, while en route to his home in Florida on Friday night.

He claimed that she turned on him after he suggested that she shouldn't run for governor or senator.

"She has told many people that she is upset that I don't return her phone calls anymore," Trump said, adding, "I can't take a ranting Lunatic's call every day."

Trump also said that voters in her district "are fed up with her and her antics and, if the right person runs, they will have my Complete and Unyielding Support".

Trump has long faced criticised from both parties over his handling of the US Department of Justice's files related to Epstein, the late financier and convicted paedophile.

Trump was a friend of Epstein's for years, but the president has said they fell out in the early 2000s, two years before Epstein was first arrested. Trump has consistently denied any wrongdoing in relation to Epstein.

Greene is one of four House Republicans - including Nancy Mace, Lauren Boebert, and Thomas Massie - who joined Democrats in signing a discharge petition calling for the release of the Epstein files.

In response to Trump, Greene posted on X that Trump was trying to stop other Republicans from voting in favour of the Epstein petition.

"He's coming after me hard to make an example to scare all the other Republicans before next weeks vote to release the Epstein files," she posted, adding: "It's astonishing really how hard he's fighting to stop the Epstein files from coming out that he actually goes to this level."

Greene has in recent days been attacking Trump for not doing enough to bring down costs for voters, and for his involvement in foreign conflicts, and tariff policies.

But she has also fiercely criticised his approach to handing the Epstein files.

"I truly just stand with the women, and I think they deserve to be the ones that we're fighting for," she told the BBC's US partner, CBS News, earlier on Friday.