Manchester United's hopes of mounting a serious Premier League title challenge were damaged as Charlie Austin scored on his Southampton debut to earn a 1-0 win at Old Trafford on Saturday.
Cameron Borthwick-Jackson was the only change from the XI which won at Anfield, and Van Gaal's side again started slowly with few chances to speak of in another forgettable first half for Old Trafford supporters.
January signing Austin came off the bench for Ronald Koeman's side 11 minutes from time and headed home James Ward-Prowse's free kick on 87 minutes to earn Southampton their second league win at Old Trafford in two seasons.
Liverpool snatched a 5-4 victory at Norwich City thanks to an Adam Lallana winner deep into injury time.
Roberto Firmino had made the breakthrough on 18 minutes, but Norwich drew level just before the half-hour mark when Dieumerci Mbokani sent a superb backheel past Simon Mignolet in the Liverpool goal.
Steven Naismith, who joined Norwich from Everton this week, then fired home from a difficult angle to mark his debut with a goal.
Norwich extended their advantage on 54 minutes through a Wes Hoolahan penalty, but Jordan Henderson swept home 96 seconds later and Firmino made it 3-3 with just over an hour gone.
Norwich's Russell Martin then played a sloppy backpass to allow James Milner to run clean through and slot past Rudd to make it 4-3 on 75 minutes only for Sebastien Bassong to fire home an equaliser in injury time.
Yet Lallana would have the last word, bouncing a shot past Declan Rudd in the final seconds of the game to spark wild celebrations.
Leicester City moved three points clear at the top of the Premier League with a 3-0 win over Stoke City.
Leicester took the lead two minutes before half-time with a 20-yard half-volley from Danny Drinkwater.
Jamie Vardy then netted for the first time since Dec. 14, latching on to a Drinkwater throughball before stylishly putting away his 16th goal of the season.
Leicester wrapped up the victory when Riyad Mahrez set up substitute Leonardo Ulloa.
The result sees the Foxes, who had trailed Arsenal on goal difference at the start of the day, go clear at the top ahead of the Gunners' game against Chelsea on Sunday.
Sergio Aguero rescued a point for Manchester City as Manuel Pellegrini's side could only draw 2-2 at West Ham.
The Hammers took the lead after just 53 seconds, with Cheikhou Kouyate battling past Yaya Toure down the left wing and crossing for Enner Valencia to finish low past Joe Hart. That goal was the second-quickest scored in the Premier League this season, but City recovered quickly.
Aguero was brought down in the Hammers area after a needless foul from Carl Jenkinson, and sent Adrian the wrong way from the penalty spot to equalise after nine minutes.
Nicolas Otamendi failed to deal with a long throw from Michail Antonio, and Valencia easily outmuscled the centre-back before finishing coolly past Hart for the lead.
Slaven Bilic's side looked to see out the game for three points, but Aguero again capitalised on some desperate West Ham defending as he latched onto a loose ball in the box before netting past Adrian for a share of the spoils.
Tottenham Hotspur came from behind to beat Crystal Palace 3-1 at Selhurst Park as Dele Alli scored a stunning late goal.
Palace — who had not scored a league goal since Dec. 19 — took the lead when Jan Vertonghen diverted the ball into his own net from a Wilfried Zaha cross.
Spurs hit back through Harry Kane on 63 minutes, with the England striker heading home from substitute Nacer Chadli's cross for his 12th goal in his last 14 Premier League games.
Palace, on a run of three straight defeats going into the game, nearly restored their advantage with 10 minutes to play but both Scott Dann and Mile Jedinak struck the woodwork in quick succession following a free kick.
Their failure to score was to prove costly as Alli controlled the ball, flicked it over Jedinak's head and then volleyed past Wayne Hennessey in the Palace goal.
Chadli then curled home a third late on to ensure victory.
Watford ended a four-game losing streak with a 2-1 win against Newcastle United.
Odion Ighalo opened the scoring just 44 seconds into the second half, with Troy Deeney dinking the ball over the defence before the Nigeria international took the ball around keeper Rob Elliot to slot home.
Watford defender Craig Cathcart then thundered home a second just before the hour mark to leave Newcastle in serious trouble.
However, Jamaal Lascelles scored with a header from a Jonjo Shelvey corner on 71 minutes
West Bromwich Albion and Aston Villa played out a goalless draw in the West Midlands derby.
Villa were denied an early penalty when Jordan Ayew went down under a Jonas Olsson challenge, but referee Robert Madley waved away the appeals.
Sunderland and Bournemouth drew 1-1 in their relegation battle at the Stadium of Light.
Benik Afobe opened the scoring on 13 minutes with a fine header from Junior Stanislas' cross, but Sunderland were level on the stroke of half-time through Patrick van Aanholt's left-footed strike.
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