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Sir Alex Ferguson has no fresh injuries or suspensions to contend with ahead of Saturday's clash with the Gunners, so the Manchester United boss is likely to ring in the changes from the midweek Capital One Cup defeat at Chelsea and name the same side that beat the Blues 3-2 in the Premier League last Sunday.
Robin van Persie will lead the line for the Red Devils against his old club with Wayne Rooney assuming a deeper role once again, with support from Antonio Valencia and Ashley Young on the wings.
Shinji Kagawa (knee) has been ruled out until the end of November, while Nemanja Vidic (knee) is still out. Phil Jones (knee) and Chris Smalling (metatarsal) are both nearing a return but Saturday may be too soon for either to launch a comeback.
Arsenal will have to cope without their top scorer in the league Gervinho after the Ivory Coast international injured his ankle after coming on as a sub against QPR last week, meaning Arsene Wenger is likely to stick with the team that forced a late win over Mark Hughes' side.
Kieran Gibbs (hip) is still out for the Gunners, meaning Andre Santos will continue at left-back, while Vito Mannone will start in goal with Wojciech Szczesny (ankle) still fighting to recover.
Theo Walcott is pushing for a start after his midweek Capital One Cup heroics against Reading, but it is more likely that Wenger will keep the England international on the bench after 120 minutes of football.
DID YOU KNOW?
The last time Manchester United and Arsenal met at Old Trafford - when the Red Devils won 8-2 in August 2011 - was the highest-scoring match between the two in history.
Arsenal's last victory at Old Trafford came courtesy of an Emmanuel Adebayor goal in 2006. Theo Walcott is the only current Arsenal player who was in the squad for the 1-0 victory.
Sir Alex's side have won nine of their last 10 meetings with the Gunners in all competitions.
The Red Devils have scored and conceded at least two goals in the same Premier League game five times this season.
Robin van Persie (pictured right) has hit the woodwork 21 times since August 2009; nine more times than any other Premier League player in the same period.
Only one of the Gunners' 14 league goals this term have come before the half-hour mark.
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