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League leaders Chelsea began 2015 on a sour note when they fell to Tottenham 5-3 on New Year's Day, but the Blues will hope to reestablish their dominance at the top when Newcastle head to Stamford Bridge.
Defending Champions Man City face Everton without four time African footballer of the year Yaya Toure, Arsenal are home to Stoke City while Liverpool face Sunderland away.
In Spain Leaders Real Madrid take on Espanyol while the troubled Barcelona play holders Atletico Madrid and in Italy holders and leaders Juventus face a nervy trip to Napoli with As Roma waiting to take advantage of any slip .
Watch ViaSat 1's Thierry Nyann and seasoned Sports pundit Jessy Amponsah as we dissect some of Week 21's biggest collisions with predictions on Touchline.
Touchline features two pundits who are forced to deliver succinct and assertive opinions within a thoroughly limited time frame yet providing viewers a quick sense of what to expect during the weekend's eagerly anticipated crunch games. "Touchline with George Addo Jnr" is strictly online , Uploaded on Friday Nights and could be accessed on Myjoyonline , Face book, Twitter Youtube and soon to be introduced online platforms.
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