An Amazon cargo plane barreled off a runway at Miami International Airport on Sunday, killing at least five people as it struck vehicles and burst into flames, authorities said.

The aircraft overran the runway around 2 p.m. after arriving from San Juan, Puerto Rico. Five people were killed, three critically injured and two others hospitalised with less severe injuries, Miami-Dade County officials told a news conference.

Miami-Dade Rescue Fire Chief Ray Jadallah said some people were trapped inside vehicles. The pilot and copilot were also trapped in the plane. Fire crews were still dealing with a fuel leak on the plane several hours after the crash, Jadallah said.

More than 60 Miami-Dade Fire Rescue units responded to the crash, arriving to find the aircraft on fire as crews worked to extinguish the flames and assess patients.

The Prime Air plane came to rest beside a roadway near two semi-trucks, according to images from the scene. The aircraft appeared to be resting on its belly and was largely intact despite the fire.

The flight had been operated by 21 Air, a cargo carrier based in North Carolina. The 32-year-old Boeing 767 was originally built to carry passengers and flew for several airlines for more than two decades before being converted to a cargo plane in 2015, according to flight-tracking site Flightradar24.

About 250 flights were delayed at the airport late Sunday afternoon, according to FlightAware, a website that tracks flight disruptions.

The National Transportation Safety Board said it is sending a team to Miami led by Chairwoman Jennifer Homendy to investigate.

“We’re working closely with local authorities and officials to understand exactly what happened,” Amazon spokesperson Kelly Nantel said in a social media post. “Right now, our absolute priority is the safety, well-being, and care of everyone involved.”