Only Algeria, Egypt and Ivory Coast will definitely be in the draw on 16 September for the final round of play-offs in African qualifying for next year’s World Cup.
The other seven places will be decided this weekend in a campaign that has been made all the more dramatic by recent results having to be overturned by Fifa because of the use of ineligible players.
Groups F, I and J will all be determined by head-to-head clashes – as well as those matches BBC Sport previews all the games in Groups F-J.
Only the 10 overall group winners will advancing to the final round of play-offs, with the first legs played between 11-15 October and the return legs 15-19 November.
Saturday: Kenya v Namibia (Nairobi), Nigeria v Malawi (Calabar)
Nigeria host Malawi in Calabar in a match that has been overshadowed by a racism row.
African champions Nigeria need only a point to win the group while The Flames must win the tie to finish top.
Belgian coach Tom Saintfiet has taken charge of Malawi with the sole purpose of beating Nigeria and helping the Flames qualify for Brazil, so much so he is working with the team for free and has given up any potential win bonus.
But a request from the Football Association of Malawi to have the venue of the match switched from Calabar on security grounds lead to an angry outburst from Nigeria boss Stephen Keshi, with his comments being reported to Fifa.
Keshi has recalled Nosa Igiebor to his squad for the match, as the coach attempts to concentrate on the match rather than the controversy off the pitch.
For his part, Saintfiet dropped vice-captain Luck Malata from his squad at the last moment.
The defender, who missed July’s Cosafa Cup in Zambia to undergo trials in South Africa, played in Malawi’s 1-0 friendly loss to Botswana on Tuesday but the coach has decided he is no longer required.
Saintfiet did not even include regular captain Joseph Kamwendo in his squad for the match so he must now decide on a new leader for Saturday’s match.
Meanwhile, the Belgian was dismayed by the loss in Botswana, following a goal from Jerome Ramatlhakwana.
“I’m disappointed to have lost the game because I hate losing. I feel that the goalkeeper (Charles Swini) should have done better to deal with the cross which led to the goal,” he told the FA of Malawi (Fam) website.
“We played well in the first half but we let Botswana come at us in the second half.”
Kenya host Namibia in the other game in this group where a win for the Harambee Stars would see them avoid finishing bottom of the group.
Sunday: Zimbabwe v Mozambique (Harare), Tuesday: Egypt v Guinea (Alexandria)
Egypt are looking to maintain the only 100% record in the African qualifiers when they play Guinea in a match that does not take place until Tuesday.
With continued security problems in Cairo, the match will be played in Alexandria.
Conversely on Sunday in Harare, Zimbabwe face Mozambique as both nations try to register their first wins of the campaign.
Sunday: Benin v Rwanda (Porto Novo), Tuesday: Algeria v Mali (Blida)
Algeria are another nation who have already secured their place in the play-offs and so can begin their preparations for those ties when they host Mali on Tuesday.
On Sunday, Rwanda travel to play Benin in search of their first Group H victory.
Sunday: Cameroon v Libya (Yaounde), Togo v DR Congo (Lome)
Sunday’s encounter in Yaounde is another winner-takes-all match as Cameroon host Libya.
The Indomitable Lions only need to draw to advance thanks to yet another ineligible player – this time Togo’s Alexis Romao, who should have been suspended but played when the two teams met in June.
Togo won the game on the day but Fifa overturned that result and awarded Cameroon a 3-0 win that leapfrogged them above Libya to the top of the group.
Instead of needing to win, Cameroon now only need to avoid defeat to advance. Only a win will be good enough for Libya.
Despite this, Indomitable Lions midfielder Eyong Enoh insists Cameroon are going for all three points.
“The game on Sunday against Libya is serious business, and the players are hungry for victory,” he said.
“We are not going to play for a draw. Everybody’s mind is made up to win the game, and to win we need to score goals.”
“With the return of Eric-Maxim Choupo-Moting and Samuel Eto’o and hopefully with aggressiveness and purposeful play, Cameroon should be able to score goals and get a victory.”
Germany-based striker Choupo-Moting returns from injury and is determined to give his best.
“Playing at home in Cameroon, a big football nation, our goal is to beat every team at home,” he insisted.
“We did not score in the last two games and I will help the team to score goals and play better football.”
The overturned result means Togo are another side looking for their first win in the group, as they host DR Congo in what will be the last game for coach Didier Six.
Saturday: Angola v Liberia (Lubango), Senegal v Uganda (Marrakesh)
One match will decide the winner of this group as Senegal ‘host’ Uganda on Saturday.
Yet the game is being played on neutral territory in the Moroccan city of Marrakesh as there is still a ban on the use of Senegal’s home stadium in Dakar.
The ban is in place after crowd trouble affected an Africa Cup of Nations qualifier against Ivory Coast last year.
The Teranga Lions need just draw to advance while Uganda have to win the match to progress.
There is no Demba Ba in the Senegal team after he was dropped by French coach Alain Giresse.
Fellow striker Papiss Cisse is also absent, suspended after picking up two yellow cards in earlier qualifiers.
Uganda prepared for the match with a training camp in Turkey and dropped striker Geoffrey Massa from the squad because coach Milutin ‘Micho’ Sredojevic felt he was ‘unfit’.