Jurgen Klopp will bid to reach the quarter-finals of the Capital One Cup with Liverpool against Bournemouth, while also trying to get his first win in charge.
Liverpool have drawn all three matches under the former Borussia Dortmund manager, the most recent game being a 1-1 draw with Southampton on Sunday.
Klopp will likely make changes as his side play Chelsea in the Premier League at Stamford Bridge three days after the tie.In the league, Bournemouth have lost their last two games, conceding 10 goals.
Manchester United entertain Middlesbrough in the Capital One Cup last 16 on Wednesday night with both sides riding high in their respective leagues.
United are currently fourth in the Premier League following Sunday's goalless draw with Manchester City, with the club having lost just one of their last eight matches in all competitions.
It is expected that Louis Van Gaal will field a strong line-up against 'Boro as United's head coach looks to win his first trophy since taking charge of the Red Devils last summer.
And one player who is set to be handed his chance at Old Trafford is midfielder Jesse Lingard after the 22-year-old's impressive display against City, with defender Phil Jones praising his team-mate after the game.
Middlesbrough travel to United sitting in fourth place in the Championship after Saturday's comeback victory at Wolverhampton Wanderers, a win that was sealed by Stewart Downing's late free kick.
Downing only started on the bench at Molineux after picking up a rib injury in the club's previous game at Cardiff City, but the wide man is expected to start against United.
"I took a whack in the ribs at Cardiff; I'm not sure if there is a break there or not, but I'm told there is nothing you can do so I just decided to get on with it," he told the club's official website.
Meanwhile, 'Boro head coach Aitor Karanka could also hand midfielder Bruno Zuculini his debut against United after signing the Argentine on a month's loan from Manchester City on Monday.
Crystal Palace will need to win at Manchester City for the first time since 1990 if they are to reach the Capital One Cup quarter-finals.
Alan Pardew's side, who have never won the League Cup or FA Cup, have striker Dwight Gayle back from a ban for the trip to the Premier League leaders.
City midfielder Samir Nasri returned to training this week after a hamstring injury but is not yet match fit.
Sergio Aguero and David Silva remain out, while Fernandinho is suspended.
City manager Manuel Pellegrini fielded a strong side in this competition last time out as his side swept Sunderland aside 4-1 at the Stadium of Light.
But with a key Champions League trip to Sevilla scheduled three days after the weekend's home meeting with Norwich, Pellegrini could shuffle his pack.
Lifting the trophy this season would move City – winners in 2014 – on to four League Cup wins, as many as rivals Manchester United.
Southampton host Aston Villa in the Capital One Cup fourth round on Wednesday night looking to take advantage of their opponents' current struggles.
Villa parted company with boss Tim Sherwood after the club's 2-1 defeat to Swansea City at Villa Park on Saturday, their sixth successive Premier League loss.
Kevin MacDonald will take charge of Villa for their trip to the south coast, and the caretaker coach is expected to make use of a fully-fit squad by giving a number of recently unused players a run-out at St Mary's.
Two players in particular who could benefit are Libor Kozak – the striker's only previous appearance this season came in the club's third-round win over Notts County – and out-of-favour winger Charles N'Zogbia.
Southampton manager Ronald Koeman is also set to follow MacDonald's lead, with Gaston Ramirez in line to feature against Villa after the midfielder came off the bench to create the Saints' equaliser against Liverpool on Sunday.
"Gaston is working hard and he's part of the team. He was not the first option in that position in front," Koeman told Southampton's YouTube channel.
"He's working hard and he's trying to take his opportunity. With injuries to Shane [Long] and Jay [Rodriguez] he's knocking on the door and then I give Gaston that opportunity."
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