Eighteen people are feared dead after the vehicles they were travelling in were involved in an accident at Sarekyekura, a farming community near Fufulso in the Savannah Region.
Those who died included 12 males and 4 females including a child.
Many others are said to be in a critical condition after they sustained varying degrees of injuries.
According to the Savannah Regional Fire Commander, Kwasi Baffour-Awuah, a Yutong bus with registration number AC 1699-20 from Kumasi to Garu collided with another bus with registration number GN 3345-16 travelling from Zebila to Kumasi.
He said the bus from Zebila veered off its lane into the other lane and collided head-on resulting in the casualties.
The Savannah Regional Fire Commander said both drivers died on the spot with two other people dying at the health facility they were sent to.
Meanwhile, 45 injured persons are currently receiving treatment at the Buipe Polyclinic and Holistic Medicare Hospital while all 16 bodies have been deposited at the Tamale Teaching Hospital.
The Regional Fire Service Commander is appealing to government for rescue equipment in the region.
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