In every human being, breath or air is very essential. Lack of it can cause stroke, cerebral palsy at childbirth, lack of muscle strength and sometimes death. This breath in the body is carried to essential organs in the body and any bodily organ that is deprived of this air begins to degenerate and gradually die in the process. This air is carried through a blood component in the body called hemoglobin. This hemoglobin is made (from nature or configured from nature) to last for about 120 days and it will gradually die. After death, the body produces new set of hemoglobin that starts this whole oxygen transport process.

In sickle cell persons, this essential hemoglobin does not last for the 120days that it is meant from nature to do. It lasts only about 20-25days. And the human body, despite its realization of the rapidly declined and gradual depletion of hemoglobin in the body, it does nothing to produce new hemoglobin until the end of the 120days that it is naturally meant to do. And when this happens (that is the depleted hemoglobin level), the body fails greatly in transporting air or breath to the body organs. With other conditions taking advantage of this compromise, the sickle cell person goes through severe body pains called crisis. The joints suffer most from this.

To help prevent this, drink lots of water, and one could take folic acid (but with a physician's approval) to aid and strengthen the already weak hemoglobin, one could prevent excessive physical exercise that could unnecessarily place high demands on the already fragile hemoglobin condition.