Swansea 0-4 Manchester City
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
City came into the contest averaging three goals per game and made sure that record was matched inside 52 minutes with a David Silva double and Kevin De Bruyne's free-kick.
Sergio Aguero claimed the fourth five minutes from time with his 10th league goal of the season - one more than Swansea have managed.
Silva has now scored four goals in his last three games and was at his brilliant best here, conducting the City orchestra with his passing and movement.
City's latest win of a seemingly unstoppable campaign removed Arsenal's 14-game winning streak in 2002 from the record books.
West Ham 0-0 Arsenal
Arsenal lost further ground on the Premier League pace-setters after they were held to a goalless draw at West Ham.
A frustrating evening at the London Stadium saw the Gunners dominate for long spells but they were unable to break down a stubborn home side.
And they were inches from a damaging defeat after Hammers sub Javier Hernandez hit the crossbar with a minute remaining.
While a third game without a win was another blow to Arsenal's Champions League hopes, a point was another step in the right direction for West Ham following Saturday's win over Chelsea.
Tottenham 2-0 Brighton
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Spurs dominated another uninspiring contest at Wembley and needed a hefty slice of luck to take the lead as Aurier's cross dropped into the top corner. Son added a second late on.
Tomer Hemed could have pulled Brighton level with a rare second-half chance but Tottenham were worthy winners and move back into the Champions League spots after Liverpool slipped up against West Brom.
Brighton stay 13th, three points above the relegation zone.
Manchester United 1-0 Bournemouth
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Runaway Premier League leaders Manchester City brought an untimely end to United's club record-equalling 40-match unbeaten home run on Sunday, when Pep Guardiola's men opened up an 11-point cushion over their second-placed rivals.
Jose Mourinho's Reds rallied after that potentially season-defining defeat by securing a hard-fought 1-0 win at home to Bournemouth through Lukaku's first-half header.
It was just the Belgium striker's third United goal in 15 matches - a poor run that has led the summer signing to come under scrutiny, especially in the wake of Sunday's derby defeat.
Liverpool 0-0 West Brom
Liverpool manager Jurgen Klopp reunited the 'Fab Four' but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Prior to this game the Reds averaged a goal every 23 minutes when Mohamed Salah, Sadio Mane, Roberto Firmino and Philippe Coutinho were on the pitch but on this occasion they could not find the net in almost four times as long.
For the second time in four days Klopp was left raging at the officials after substitute Dominic Solanke's late goal was ruled out for handball by an assistant referee having initially been given by referee Paul Tierney.
The Reds boss had been unhappy about the award of Everton's penalty in Sunday's Merseyside derby and he was equally unimpressed by this decision.
Newcastle 0-1 Everton
Wayne Rooney's 10th goal of the season condemned Newcastle to a seventh defeat in eight Premier League outings as the home fans prayed for Mike Ashley's exit from St James' Park.
Rooney pounced on goalkeeper Karl Darlow's 27th-minute error to stab home the only goal of the game in a first half which saw the Magpies, who had Jonjo Shelvey sent off in stoppage time, hit both posts.
Rafael Benitez's men enjoyed the better of the game for long periods in front of a crowd of 51,042, many of whom arrived having read reports that prospective owner Amanda Staveley is close to agreeing a Ł300million deal with owner Ashley to end his controversial 10-year-plus reign.
But they left having seen Sam Allardyce, who was sacked by Ashley in 2008 after just eight months in charge, extend his unbeaten start as Toffees boss to four games with a 1-0 win.
Southampton 1-4 Leicester City
Claude Puel exacted revenge on his first return to Southampton as Leicester romped to a 4-1 Premier League win at St Mary's.
Shinji Okazaki's brace and further goals from Riyad Mahrez and Andy King eased Leicester past the struggling Saints, who could only muster a scrappy effort from Maya Yoshida.
Frenchman Puel was sacked in the summer despite last term leading Southampton to an eighth-place finish and the League Cup final.
The former Nice boss was out to disprove accusations he had favoured boring football in his Saints tenure, and revelled in his Leicester charges laying on plenty of entertainment.
The same shortcomings that littered Puel's Saints tenure were on display for Mauricio Pellegrino's men, however, with the hosts finding no fluency in attack and defending pitifully.
New boss Pellegrino's Southampton stint now appears under real strain: Saints boast just one win and six points in their last eight Premier League games.