Fire Sunday morning gutted several stores at the Kantamanto market, at the central business district of Accra.
It is not clear what caused the inferno but the damage caused is estimated to run into thousands of Ghana cedis.
Eyewitnesses say the fire started around 5am Sunday and affected a greater part of the market.
Personnel from the Ghana National Fire Service managed to contain the blaze after battling it for several hours.
Even though the fire has been brought under control, a billow of smoke could still be seen at the area known for the sale of several items including second hand clothes popularly known as “Broni waawu”.
Some of the affected who spoke to Joy News’ Nana Agyei Essuman said all their investments have gone down the drain.
A lady recounted that, “a friend of mine called me to come. She told me that something had happened but she didn’t tell me what exactly it was. I got here to realise that this place is burnt; I can’t find my things… I just hope and pray I find my things.”
A man said he rushed to the market as soon as he heard of the outbreak. According to him, his wife has lost about 15 bales of clothes in the incident.