After their morale-boosting victory against the Phobians on Monday, Kotoko look set to beat the bottom-of-the-table Dwarfs.
For Hearts of Oak, the best away form in the league means they are favourites to win at Berekum Chelsea. Meanwhile, Techiman City, unbeaten in five home games, will be tested by visiting league leaders Wa All Stars.
There are more talking points here, including the effect of Hearts' three-match home ban and more.
Analysis by Joy Sports Gary Al-Smith and Kweku Arhin.