Shops, restaurants, and schools will be closed across most of Italy on Monday, with PM Mario Draghi warning of a "new wave" of the coronavirus outbreak.
For three days over Easter, 3-5 April, there will be a total shutdown.
Italy, which one year ago imposed one of the first national lockdowns, is once again struggling to contain the rapid spread of infections.
The country has reported more than 100,000 Covid-related deaths, Europe's second highest tally after the UK.
Italy's vaccination campaign has been hit by delays, as has been seen elsewhere in the European Union.
Last week the government in Rome blocked the export of 250,000 doses of the Oxford-AstraZeneca vaccine to Australia in a bid to address shortfalls of vaccines.
Elsewhere, Bulgaria, Denmark and Norway have all paused the use of the Oxford-AstraZeneca vaccine over fears it causes blood clots.
The World Health Organization said on Friday there was no indication this was true, stressing that countries should not stop using the vaccine.
In other developments across Europe:
- Poland registered nearly 19,000 new daily cases on Friday - the highest number since November
- Germany reported a rapid rise in infections among schoolchildren, with new Covid variants blamed
- In France, the number of patients in intensive care units exceeded 4,000 - the record figure for more than three months. The government has not ruled out more regional lockdowns
- Slovakia and the Czech Republic were hit by government crises over buying non-EU approved vaccines
What are the new rules in Italy?
From Monday, schools, shops and restaurants will shut in more than half of Italy, including the two most populous regions containing Rome and Milan.
Residents will be required to stay home except for work, health or other essential reasons.
The extra restrictions would last until Easter, Mr Draghi's office said, and over the Easter weekend the whole country would be turned into the high-risk "red zone".
"I'm aware that today's restrictions will have consequences on the education of your children, on the economy and on everyone's mental health," Mr Draghi said.
"But they're necessary to avoid a worsening of the situation that would require even stricter measures."
Cases have been rising across Italy for the past six weeks, exceeding 25,000 a day.
In a majority of the country's regions "hospitals and above all intensive care units are already overloaded", the GIMBE health think-tank warned this week, the AFP news agency reported.
The island of Sardinia is the only region where infections rates are low.
Italy has had nearly 3.2 million confirmed infections since the outbreak began last year.
Latest Stories
-
YAWC Network Ghana chapter holds National summit in Accra
10 seconds -
Memories of a Baby Univers
11 mins -
Akufo-Addo calls for peaceful elections, says politics shouldn’t divide us
27 mins -
Yinson, West African Rescue Association and Ahanta West Municipality tackle malaria
35 mins -
NHIA releases over GHS170m to settle healthcare providers
55 mins -
GFA will continue to support clubs in Africa – Kurt Okraku promises
57 mins -
Oheneyere Mrs. Helen Opong-Kesse
1 hour -
University of Ghana Stadium to host WAFU B U-17 Cup of Nations
1 hour -
Support us to demand better conditions of service – TEWU OF TUC tells members
1 hour -
CAFCC: Dreams FC holds dinner to honour players for reaching the semi-finals
2 hours -
200 students selected for KNUST e-learning ambassador training
2 hours -
KNUST gets its first virtual reality studios to boost teaching and learning
2 hours -
Don’t short-change labour under the guise of global economic recession – ICU-Ghana to government
2 hours -
We must guard against employers who want to short change us – ICU tells members
2 hours -
Dreams FC proved Ghanaian clubs can win CAF inter-club trophies – Ameenu Shardow
2 hours