Ghana Premier League champions Medeama S.C. will face Congolese giants Tout Puissant (T.P.) Mazembe in the preliminary round of this season’s CAF Champions League.

The Tarkwa-based side will host the first leg at the TnA Stadium on the weekend of September 4-6, 20206.

Medeama will then travel to the Democratic Republic of Congo for the reverse fixture the following weekend.

Mazembe won the first meeting between the two sides; a 3-1 win on June 19, 2016, in a CAF Confederation Cup group stage match in Lubumbashi.

A month later, Medeama S.C. won the reverse fixture by 3-2 at the Accra Sports Stadium.

If they qualify, Medeama will face either Tunisia's Club Africain or Mali's Djoliba AC in the second preliminary round.

Medeama S.C. are currently in the Ivory Coast for their pre-season campaign.

On Wednesday, they defeated Yamoussokro F.C. 2-1 in their first pre-season friendly.

Meanwhile, FA Cup winners Nations F.C. have been drawn against F.C. Diarra in the CAF Confederations Cup.

Diarra will host Nations F.C. in Mali for the first leg, scheduled for September 4–6, 2026.

Nations F.C. will then host the reverse fixture in Ghana on the weekend of September 11 and 13.

Should they qualify, Nations FC will take on the winner of the tie between Niger's AS Zam and Togo's ASKO de Kara in the second preliminary round.