Manchester United were given a harsh reality check at Old Trafford as Alex Iwobi's injury-time effort gave Fulham only their second Old Trafford victory since 1963.
Four days after new co-owner Sir Jim Ratcliffe spoke of United attempting to knock Manchester City and Liverpool off their perch at the top of the English game, they suffered a major blow to their hopes of Champions League qualification.
Without injured striker Rasmus Hojlund, the hosts were ineffective in attack until the final minute of normal time, when Harry Maguire seemed to have rescued a point for the hosts.
But Iwobi had the final say deep into nine minutes of stoppage time, restoring an advantage initially given to them by Nigeria defender Calvin Bassey, who lashed home the loose ball after his header from a Fulham corner had been blocked by team-mate Timothy Castagne.
The result ended a run of 11 Premier League away games without a win for the west London outfit. Prior to this contest, only Sheffield United had a worse top-flight away record this term.
Neither the defeat nor, more importantly, the performance, will give anyone the belief United will achieve Ratcliffe's lofty aims any time soon.
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