It is the last quarter-final contest of the 2021 National Science and Maths Quiz (NSMQ) featuring two-time champions Opoku Ware SHS, Oda SHS and Ghana SHS, Koforidua.

Any of these schools that qualify will face Prempeh College and KNUST SHS at the semi-final stage.

The semi-final clash becomes an Ashanti warfare if Opoku Ware SHS wins.