The Duke and Duchess of Sussex are to split from the charity they shared with the Duke and Duchess of Cambridge to set up their own foundation.
Prince Harry and Meghan will break away from the Royal Foundation and hope to establish a new charity by the end of the year, according to royal aides.
The couples will continue to work together on initiatives such as the Heads Together mental health campaign.
The foundation said the royals were "incredibly proud" of their joint work.
Set up in 2009, the Royal Foundation focused on causes close to the princes' hearts, including the armed forces, conservation and mental health.
In a statement, the charity - which will be renamed the Royal Foundation of the Duke and Duchess of Cambridge - said the decision was made after a review of its structure.
Image captionThe four royals held the first - and so far only - Royal Foundation forum together in London in 2018
"These changes are designed to best complement the work and responsibilities of Their Royal Highnesses as they prepare for their future roles, and to better align their charitable activity with their new households," it added.
"The Duke and Duchess of Cambridge and The Duke and Duchess of Sussex are incredibly proud of what they have achieved together through the Royal Foundation," it said.
Catherine joined after she became Duchess of Cambridge in 2011 and Meghan joined shortly before she and Harry were married in May 2018.
The couples took to the stage together at the charity's first forum in London in February 2018. The charity's title was later officially changed to The Royal Foundation of The Duke and Duchess of Cambridge and The Duke and Duchess of Sussex.
The move by the Sussexes is seen as the final step in the division of the couples' public duties.
Image captionThe royal charity said the dukes and duchesses were "incredibly proud" of the work they have done together
Image captionThe Heads Together campaign was launched in 2016 by the Duke and Duchess of Cambridge and Prince Harry to end the stigma around mental health
Earlier this year the duke and duchess split from the household of Kensington Palace, where William and Kate live with their children.
Prince Harry and Meghan appointed a separate head of communications and set up their own Instagram account.
They also moved to Frogmore Cottage, Windsor, in April - shortly before Meghan gave birth to their son Archie.
Latest Stories
-
Burkina Faso suspends BBC, VOA radio broadcasts over killings coverage
2 mins -
Nicole Kidman honoured with AFI Life Achievement Award
14 mins -
Brassier scores winner for Brest as they edge Rennes to secure European football
34 mins -
‘What are the real causes of the erratic power outages?’ GUTA demands from ECG
55 mins -
Implementing ESG framework in Ghana’s energy sector for sustainability
1 hour -
CAFCC: Dreams FC exit competition after 3-0 defeat in Kumasi
1 hour -
The detrimental effects of political interference on Ghana’s electricity sustainability
2 hours -
Prof. Opoku-Agyemang’s appointment as running mate intimidates the NPP – Benjamin Quashie
2 hours -
Black Stars physical trainer dead
2 hours -
Bawumia to kick off nationwide campaign for Election 2024 tomorrow
2 hours -
GUTA charges ECG to provide ‘dumsor’ timetable for businesses to plan
2 hours -
Reason for training professional counsellors is to heal a hurting world – CCP president
4 hours -
Woman allegedly brings dead man to bank to take out a loan
4 hours -
It’s a good feeling to score against PSG because I’m a Marseille boy – Andre Ayew
5 hours -
Joe Lartey Sr: A voice that brought life to Ghana sports and beyond
5 hours