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Manchester United will play Real Betis in the Europa League last 16 after overcoming Barcelona, while Arsenal face Sporting Lisbon.
United beat the La Liga leaders 2-1 at Old Trafford on Thursday to seal a 4-3 aggregate win in the play-off tie.
Arsenal will play the second leg of their tie at home after qualifying as group winners, while Manchester United host Betis at Old Trafford first.
The Europa League last-16 ties will take place on 9 and 16 March.
Premier League leaders Arsenal avoided the knockout round play-offs by topping Group A with five wins from their six games.
Elsewhere, six-time winners Sevilla meet Fenerbahce, while Jose Mourinho's Roma will play Real Sociedad - who topped Manchester United's group.
The eight Europa League group winners were drawn against the eight clubs who came through the knockout round play-off matches, with clubs from the same association not allowed to be drawn against each other.
Europa League last-16 draw
Union Berlin v Union Saint-Gilloise
Sevilla v Fenerbahce
Juventus v Freiburg
Bayer Leverkusen v Ferencvaros
Sporting Lisbon v Arsenal
Manchester United v Real Betis
Roma v Real Sociedad
Shakhtar Donetsk v Feyenoord
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