Chelsea will face holders Real Madrid in the Champions League quarter-finals.
Pep Guardiola faces his former club as Manchester City play six-time winners Bayern Munich.
Inter Milan face Benfica and Serie A champions AC Milan take on current leaders Napoli.
If Chelsea and Manchester City get through, they will meet in an all-Premier League semi-final while AC Milan or Napoli will face Inter Milan or Benfica in the other semi-final.
The first legs of the quarter-finals take place on 11-12 April, with the return games on 18-19 April.
The first legs of the semi-finals will be on 9-10 May, and the second legs on 16-17 May.
The Ataturk Olympic Stadium in Istanbul, Turkey, will host the final on 10 June.
Champions League quarter-final draw
Real Madrid v Chelsea
Inter Milan v Benfica
Manchester City v Bayern Munich
AC Milan v Napoli
Champions League semi-final draw
AC Milan or Napoli v Benfica or Inter Milan
Real Madrid or Chelsea v Manchester City or Bayern Munich
‘Fiercely tough routes’ – analysis
Phil McNulty, BBC Sport chief football writer
Chelsea and Manchester City have been handed fiercely tough routes towards the Champions League final in Istanbul.
Graham Potter’s Chelsea have improved recently but they will be firm underdogs against holders Real Madrid, who disposed of Liverpool with ease in the last 16. Real are led by former Chelsea boss Carlo Ancelotti, the only manager to win the tournament four times.
Manchester City, seeking their first Champions League crown, will be favourites against Bayern Munich but the Bundesliga champions have such a rich history in the tournament and proved their pedigree by knocking out Paris St-Germain. They can never be underestimated.
Bayern also have fit-again former Liverpool striker Sadio Mane, who was a constant thorn in the side of City and manager Pep Guardiola during a stellar career at Anfield, which included a Champions League win and two losses in the final.
With the last-four draw also made, there is now the possibility of an all-English semi-final should Chelsea and City progress.
But for now both Potter and Guardiola know they must navigate a way past two giants of the Champions League who will be filled with belief that they can overcome the Premier League clubs.
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