YouTube has removed TalkRadio's channel from its platform.
The Google-owned service has not given an explanation for its action, but there is speculation that it relates to its rules on Covid-19-related misinformation.
Fact-checkers have repeatedly challenged some of the claims made by interviewees featured by the London-based radio station.
TalkRadio said it was seeking an explanation and defended its output.
"We urgently await a detailed response from Google/YouTube about the nature of the breach that has led to our channel being removed from its platform," it said in a statement posted to Twitter.
"TalkRadio is an Ofcom-licenced and regulated broadcaster, and has robust editorial controls in place, taking care to balance debate.
"We regularly interrogate government data and we have controls in place, use verifiable sources and give space to careful selection of voices and opinions."
For now, YouTube's only statement on the matter is a notification on what used to be TalkRadio's page on its platform.
"This account has been terminated for violating YouTube's Community Guidelines," it says.
The BBC has asked media watchdog Ofcom for comment.
TalkRadio has about 424,000 listeners, according to the latest figures from market research provider Rajar.
YouTube removes TalkRadio's channel from its platformhttps://t.co/7YeQHeDsPu
— BBC News (UK) (@BBCNews) January 5, 2021
It had used YouTube as a means to livestream shows from its studios and to provide an archive of past broadcasts.
It noted that it continued to stream its programmes via its own website as well as Facebook.
However, YouTube's action means that TalkRadio's website now features many articles featuring broken embedded clips, as do other outlets that embedded its material.
YouTube operates a "three strikes" policy, whereby channels that break its community guidelines three times within a 90-day period can be permanently banned, but other infractions lead to temporary restrictions.
Prohibited content includes "medically unsubstantiated claims" relating to Covid-19, and videos that contradict expert consensus from local health authorities such as the NHS.
The US firm has previously imposed a permanent ban against conspiracy theorist David Icke, and a one-week video suspension of right-wing outlet One America News Network's ability to publish new clips - in both cases for breaches of its Covid rules.
Digital rights campaign group Big Brother Watch likened the latest action to the kind of behaviour one would expect in China.
"YouTube's termination of a national broadcaster is further evidence that privatised, big tech censorship is spiralling out of control and must be challenged," its director Silkie Carlo told the BBC.
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