South African park rangers and a local wildlife organisation rescued more than 80 vultures from a mass poisoning in the country's Kruger National Park this week, though they were unable to save over 120 vultures.

South African National Parks (SANParks) and the Endangered Wildlife Trust said it was one of the largest vulture poisoning events in Southern Africa.

Officials from the organisations suspect poachers are to blame as they are increasingly using agricultural toxins to target species whose body parts are in demand for traditional medicine.

Some of the vultures rescued are classified as endangered or critically endangered, including the white-backed vulture.

The rescue was made possible by a wildlife-poisoning detection system in a remote section of the Kruger park.

After being alerted to suspicious activity, the rangers who arrived on site discovered 116 dead vultures near an elephant carcass laced with poison.

The death toll later rose to 123 vultures as more birds died on the way to a rehabilitation centre.

SANParks spokesperson Ike Phaahla told Reuters it was not clear which species the poachers were targeting but said the incident was concerning because the vultures that were killed only breed once a year.