Phil Foden and Mason Greenwood are to leave the England camp after breaking coronavirus quarantine guidelines in Iceland, says manager Gareth Southgate.
The Football Association is investigating the breaches after Saturday's 1-0 Nations League victory.
Manchester City midfielder Foden, 20, and Manchester United forward Greenwood, 18, both made their senior international debuts in the game.
Southgate described the pair as "naive" and said they have apologised.
"Two of the boys have broken the Covid-19 guidelines, in terms of our secure bubble," Southgate said on Monday.
"We had to decide very quickly that they couldn't have any interaction with the rest of the team and wouldn't be able to train.
"Obviously they have been naive. We have dealt with it appropriately. I recognise their age but the whole world is dealing with this pandemic.
"Now they will have to travel back to England separately.
"Nothing has happened in the areas we occupy in the hotel."
Greenwood's England call-up followed a breakout season at United, in which he scored 19 goals, while Foden became a regular starter in Pep Guardiola's City side in 2019-20.
A Manchester City spokesman said Foden's behaviour was "totally inappropriate" and "fell well below the standard expected of a Manchester City player and England international".
A Manchester United statement said the club are "liaising with the Football Association and are disappointed with the actions of Mason Greenwood".
England face Denmark in the Nations League on Tuesday.
Latest Stories
-
Reason for training professional counsellors is to heal a hurting world – CCP president
2 hours -
Woman allegedly brings dead man to bank to take out a loan
2 hours -
It’s a good feeling to score against PSG because I’m a Marseille boy – Andre Ayew
3 hours -
Joe Lartey Sr: A voice that brought life to Ghana sports and beyond
3 hours -
Bawumia promises to tackle issue most dear to Ghanaians as he begins nationwide campaign
4 hours -
Indian couple donate $24m fortune to charity to adopt monkhood
5 hours -
Australians call for tougher laws on violence against women after killings
5 hours -
African Development Council establishes mission in Benin for Francophone countries
5 hours -
Okyeame Kwame reveals his secret to longevity in music industry
5 hours -
Youthful-looking 60-year-old woman qualifies for Miss Argentina contest
6 hours -
Ejisu By-Election: Campaign heats up as NPP holds final rally ahead of Polls on Tuesday
6 hours -
Rwanda plan: Irish government wants to send asylum seekers back to UK
6 hours -
Ice cubes now cost more than bread and milk in parts of Mali
8 hours -
Titanic gold pocket watch sells for £900,000
9 hours -
Elon Musk in China to discuss enabling full self driving – reports
9 hours