Tottenham and England striker Harry Kane will be out until next month after damaging ankle ligaments in Sunday's Premier League win over Bournemouth.
Spurs said in a statement that "preliminary assessments" confirmed the injury after a scan on Monday.
Kane, who has scored 35 goals for Spurs this season, injured his right ankle in a collision with Bournemouth goalkeeper Asmir Begovic.
The 24-year-old should be fit for England's World Cup campaign.
But he will miss Spurs' FA Cup quarter-final at Swansea on Saturday, as well as two England friendlies the following week.
Gareth Southgate's men travel to the Netherlands on 23 March before hosting Italy on 27 March.
England's first World Cup match is on 18 June against Tunisia.
Kane missed 10 games last season with a similar injury to the same ankle in a game at Sunderland in September 2016.
He injured the same ankle again in Tottenham's FA Cup quarter-final victory over Millwall in March 2017. On that occasion, he was out for four weeks.
"Disappointing to be out until next month but injuries are part of the game," he wrote on Twitter. "Will do everything I can to get back out there ASAP."
Have your say
More Sports Headlines
- Normalisation Committee to stay on another six months
- [Infographic + video]: Why Kwesi Appiah may have no choice than to select benchwarmers
- Juventus say choosing Asia over U.S. for ICC not related to Ronaldo rape allegation
- Bijou Homes sponsors finals of 2019 Ghana Rugby Football Championship
- Joy Sports editor Ridwan Asante donates jerseys to two colts clubs
- Mybet.Africa unveil Double Win promo ahead of Ghana-Kenya clash
- Black Stars 'will give everything' for 2019 Afcon trophy - Ayew
- Ronaldo fined by Uefa over goal celebration
- Godfred Dame set to be Ghana gov't rep on new Fifa Task Force
- Pogba buys World Cup championship rings for entire France team
- Real Madrid a dream club but I'm happy at Man Utd, says Pogba
- Coca-Cola to sponsor 15 lucky consumers to watch EPL games
- Four persons accused by Gyan of extortion acquitted
- Paa Kwesi Fabin appointed coach of Uganda's youth teams
- PSG win legal battle with UEFA over FFP investigation