Reigning champions Atletico Madrid went level with Real Madrid at the top of La Liga and inflicted further damage on Ronald Koeman's struggling Barcelona with a deserved win in Spain's capital.
Thomas Lemar scored the opener, finishing well at the end of a move involving Joao Felix and Suarez.
Suarez then slotted in against his former club to put Atletico in charge.
Antoine Griezmann also featured against his former club as a late substitute as Atletico basked in their superiority.
For all the woe surrounding Barca this season, this loss was actually their first in La Liga - but it leaves them eighth in the table on 12 points, five behind Diego Simeone's side, who are second only on goal difference but have played a game more than rivals Real.
Prior to this, Barca had three wins and three draws to their name, with back-to-back chastening 3-0 losses in the Champions League doing most to harm Koeman's position at the club.
Barca had chances on Saturday, especially at 1-0, with Philippe Coutinho volleying an effort just wide and Frenkie de Jong just inches away from converting from close range following Memphis Depay's header across goal.
Coutinho also had a great chance to get the visitors back into the game in the second half but saw his shot from inside the box saved by Jan Oblak.
Despite having much more of the ball, Barcelona were second best at the Wanda Metropolitano, falling to a defeat that may well test president Joan Laporta's assertion from earlier on Saturday that Koeman would continue at the club regardless of the result in Madrid.
"It's important and well done for his part - because if everything isn't clear in this sense, then it's difficult to work and have the kind of calm you need to try to make the changes we are trying to implement," Koeman said after Saturday's game.
"We know how it is from today moving forwards... We spoke last night on the phone and then again this morning."
Barca now have a two-week break from action for internationals, with their next fixture at home to Valencia on 17 October.
"There's a solution [to what is happening], but it can't be done overnight," added Koeman. "We have to work hard, give time to the youngsters and get back our injured forwards."
Latest Stories
-
British Columbia to back off drug decriminalisation project
8 mins -
Veteran commentator Joe Lartey Sr dies at 96
9 mins -
Livestream: Newsfile discusses KPMG report on SML deal, ILO on SSNIT reserves and NDC’s running mate
42 mins -
Ghanaian activist hugs over 1,100 trees in an hour to set Guinness World Records
43 mins -
Mathew Anim Cudjoe’s Dundee United promoted to Scottish Premiership after Championship win
45 mins -
NSMQ star Jochebed Adwoa Sutherland sweeps 12 awards at UG Vice-Chancellor’s Ceremony
2 hours -
Ghana’s Education Quality ranked 125 out of 183 countries in latest Global Youth Development Index
2 hours -
Emma Stone wants people to use her real first name
2 hours -
FIFA Club World Cup 2025: Sundowns, Esperance join Al Ahly and Wydad as CAF representatives
6 hours -
CAFCL: Al Ahly set up historic final with ES Tunis
6 hours -
We didn’t sneak out 10 BVDs; they were auctioned as obsolete equipment – EC
10 hours -
King Charles to resume public duties after progress in cancer treatment
11 hours -
Arda Guler scores on first start in La Liga as Madrid beat Real Sociedad
11 hours -
Fatawu Issahaku’s Leicester City secures Premier League promotion after Leeds defeat
11 hours -
Anticipation builds as Junior Speller hosts nationwide auditions
11 hours