Arsenal have been drawn against Bayern Munich in the quarter-finals of the Champions League, while Manchester City will play 14-time winners Real Madrid.
The Gunners will host German side Bayern, who have England captain Harry Kane in their squad, at Emirates Stadium in the first leg.
Meanwhile, this is the third successive season City, who won last year's title, have met Real in the knockout stages.
The first legs take place 9-10 April, with the second legs on 16-17 April.
Both City and Arsenal play their first-leg fixtures on 9 April, with the Gunners at home to Bayern and Pep Guardiola's side at the Bernabeu.
The return legs take place on 17 April, with the two Premier League sides facing each other in the semi-finals if they win their respective ties.
In the other ties, five-time winners Barcelona will play French champions Paris St-Germain, while Atletico Madrid, who are fourth in La Liga, host German opposition Borussia Dortmund.
The semi-finals will be held on 30 April and 1 May, with the second legs a week later on 7-8 May.
Wembley Stadium will host this year's final on Saturday, 1 June.
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